Wednesday, October 2, 2024

This Cave Woman Writes


Have I mentioned how much I love 23andMe? Of course I have. I've written about my DNA tests so many times that people in cyberspace know intimate details about my body like that fact that I have an innie belly button and my eyes are brown. Having 'brown eyes' isn't exactly an intimate detail but not having a second toe longer than my big toe is and that's one of the useless facts that was revealed to me by me spitting in a little tube and sending it off for testing. I did this several years ago and they keep sending me new discoveries as the science keeps unlocking the mysteries of our genes. It's mind boggling to think about the improvements in our healthcare system when they are able to isolate the genes responsible for certain diseases. They'll be able to target and/or totally eradicate some major heartbreaking conditions. Of course, I might not live long enough to see it happen but my nieces and nephew will. It's not that far off.

This week 23andMe sent me new information about my Neanderthal gene variants. I have 32% more of them than their other customers. There are 7,462 Neanderthal traits in genome and I have 228 of them in my DNA. I've written before that on their website is a forum for customers and I found a thread about having a lot of Neanderthal genes where people were joking around about how they have to trim the hair on their toes or put Band-Aids on their knuckles from dragging them around. One woman confessed that once a month she wants to tear her husband’s arms off and suck the marrow out of his bones and now she knows why. All jokes aside, Neanderthal variants supposedly come into play with allergies and infertility issues which has my name written all over them.

How does one get Neanderthal markers in their genes? This is what 23andMe says about that: "Genetic variant that evolved in Neanderthals and came back into the human lineage when the two groups interbred. Because you inherit variants from both of your parents, you can have 0, 1, or 2 copies of the Neanderthal variant at each marker. We report your total number of Neanderthal variant copies, which is therefore a number between 0 and 7,462. However, nobody has all 7,462 — the most we've ever seen in a 23andMe customer is less than 500."

One of the newest things 23andMe reported about my Neanderthal genes is that I have one copy of the marker rs7169404 which is associated with not feeling 'hangry' when I'm hungry. I so must have gotten that one from my dad's genes because my mom definitely changed dispositions when she went without food. I also got two copies of rs3807714 regarding a preference for sweet vs salty foods. Thanks Mom and Dad. I get to blame you both for passing on our ancient ancestors lack of will power when it comes to sugary and gooey deserts. And the fact that I look at eating salads like as punishment for overeating sugary and gooey deserts? I get to blame my Neanderthal genes for not liking leafy greens. Picture me beating my fists on my chest and shouting out that I love a medium rare T-bone steak almost better than I used to love sex back in the days when I was having both. I love meat!

(At least I think I used the word "Sex" far enough into this post that the internet crawlers won't find it and spam me with advertisements. One that used to spam before I learned not to use the 'S' word in the title of my posts flooded my comment section for a cream to "enhance my sex life.)

Okay, time to change topics. What else did I do this week? I've been busy. Twice I took part in a letter writing campaign to get out the vote for Kamala Harris and our group of 12 (known) democrats here in the CCC are going keep doing two sessions a week through mid-October. I also went over to our sister campus to play Mahjong and to nail down details on a Mahjong tournament that was my brainchild to do. What a lot of work involved! More on that in a future post.

Also on the calendar this week was an infusion for my bones. That was different this time because I was the only woman there out of the 15 stations aka La-Z-Boys where we sit while hooked up with the IVs. The guy next to me was so young, cute and buff that my curiosity was peaked as to why he was there but he never woke up the entire time. First time in the ten years that I've been getting infusions that I've ever seen anyone sleeping. My younger self wanted to crawl up in his chair and spoon him. I usually pretend to read while people watching at the infusion center, looking for blog fodder but this time the book I grabbed at the last minute kept me reading. I take a book based on its weight rather than its content and I had picked a 140 page book off my shelf titled, A Guide for the Perplexed. Copyright 1977. It's filled with yellow highlighter and my handwritten notes in the margins but for the life of me I can't remember this philosophical book. But by the time my infusion was finished I concluded that I must have been a lot smarter back in the 1970s than I am now.©

Until Next Wednesday...

Photo credit: On the 3rd of August 1908, the 3 Bouyssonie brothers discovered the first complete skeleton of a Neanderthal man and the first burial site.  The remains were first studied by Marcellin Boule from the National Museum of Natural History; he described this man as the missing link between man and ape.

34 comments:

  1. What to say, what to say, well my eldest daughter did an ancestry DNA test but I don't remember what she said the results showed. People watching is so much fun, it's something I enjoy doing

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    1. It's my favorite past time. There are two places that do DNA testing and I've tried them both.

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  2. Hmm, until you said the guy was young and cute I was going to comment that men get osteoporosis too. My brother has it and I don’t so now we are back to those pesky genes again!

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    1. The infusion center treats all kinds of diseases and conditions, not just osteoporosis and the alike. I just don't see a lot of 30-somethings in there.

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  3. You might be interested in this article from The Atlantic about the troubles at 23andMe. The same concerns about privacy that kept me off Facebook kept me from ever considering one of these genetic testing sites. The issues are interesting, and bound to become more complex.

    Now that Facebook has made clear their intent to use posts from that site as a way of building their AI, I'm even happier I steered clear. I'm sure you've made your posts there private, but this is interesting, from The Verge: "The truth of the matter is that unless you have consciously set [your] posts to private since 2007, Meta has just decided that [they] will scrape all of the photos and all of the texts from every public post on Instagram or Facebook since 2007 unless there was a conscious decision to set them on private."

    I love re-reading books. I often make marginal notes, and every time I re-read a favorite, I use a different color ink, with the date in the front (e.g. "green/1987"). It is fun to see how perspective or interests change.

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    1. It makes me sad that 23andMe are in trouble. I truly believe more good than bad can come out of it. I also think I'm too close to the end of life to worry about privacy breaches there.

      Facebook is a different matter. I do have my settings at only showing to friends and I post very few photographs of myself and even fewer of family members. I worry about family members who photo-blast their young children's photo all over Facebook.

      Speaking about AL I joked about the spammer that shows up when I use the 'S' word, it happened again with this post!!!!! Same Dr. with the cream, same very long, stupid-story comment.

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  4. Thanks for working to get out the vote for Harris-Walz. We need Michigan!

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    1. I know and all the cards and letters we've worked on go out to MI and PA. These are handwritten posts and letters. Two batches comes from the Sierra Club and the other batches from the DNC.

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  5. I find this fascinating. I didn't do 23/me for DNA. Maybe I should! Love the title of that book! Happy trails. See you in November.

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    1. Before you send your sample to 23andMe you should read the articles a couple of my readers linked in their comments. Supposedly they are going under. Very sad to see and I hope it doesn't happen because too much good can comes out of their research in my opinion.

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  6. Might want to read this article from NPR. They are going under.Mary
    https://www.npr.org/2024/09/25/nx-s1-5123633/23andme-is-in-trouble-what-happens-to-all-the-dna-data#:~:text=Transcript-,Once%20a%20hot%20%246%20billion%20biotech%20company%2C%2023andMe%20is%20now,of%20its%2014%20million%20customers%3F&text=AILSA%20CHANG%2C%20HOST%3A,to%20the%20brink%20of%20collapse.

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    1. I was shocked to learn this and I hope they find away to avoid going under.

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  7. I did not know that about 23and me and the gene variants. Weird but interesting!
    I voted yesterday and am so happy to have that done. Go, Harris/Walz! Go, Blue!

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    1. I just got my ballot in the mail yesterday and plan to take care of it over the weekend. I was a little disappointed in the debate last night, that Vance didn't show is true colors and obnoxious self.

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  8. I would try to download everything you can from 23 and me right away! Someone might step up and buy them out, but you never know. I never did the traits options. I have a very boring life history. When I took a local genealogy class, I knew going in that my family went back generations and generations in my small community just from my gramma pointing out houses they used to live in. My dad's side has some big time genealogists who published a 3" think volume in the 1970's and do updates supplements every so often. When I did my dna, it just confirmed everything. No surprises. I have been working family trees on Ancestry and love finding the marriage licenses, birth and death records and most exciting - the pictures. My immediate past families included a lot of orphans and the family photos had gone to others.

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    1. Ancestry.com if great for filling in family trees but 23andMe is better for the science. Sad that they might go under. Thanks for the suggestion.

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  9. Jean, you've taught me something new (again!). I hadn't heard about the Neanderthal genes, but it does make sense, once you think about it. When you mentioned the infusion center, it reminded me of my chemo days. I still consider the medical staff there to be some of the kindest individuals I've ever met. And the generosity and concern of many in the community impressed me, too. I had to stay all day, and by mid-morning, there would be a delivery of bakery treats, at noon it wasn't unusual to have pizza or subs delivered, and then an afternoon treat. These perks were provided by individuals, churches, sororities, businesses and other various organizations in the community. Just when a person wants to throw in the towel, you run smack dab into folks who are the salt of the earth.

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    1. Same with our infusion center. The staff are great ad very pleasant and usually the other patients are too.

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  10. Another fascinating post, Jean! I had no idea they could pinpoint things that tightly and it sounds like it's getting even more exact. I haven't done DNA testing, but I have several relatives who have. The testing kits were a big Christmas gift idea in the recent past. I hope you can save your data if they go under.
    Just returned from visiting my DD on Vancouver Island (Victoria) and had overheard some great conversations on the shuttles and ferries. LOL. People watching is the best.

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    1. Ancestry.com doesn't do that kind of testing and they had lot of Christmas specials...so did 23andMe, come to think about it.

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  11. I had no idea 23andMe could provide so many interesting things about ME as a gathering of cells. Thanks for sharing all that. A neighbor (76) did the test two or three years ago. Discovered he had THREE half siblings who never knew about each other! They actually met a few times but then the spark of newness wore off. Crazy?

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    1. They probably did the testing at Ancestry. They are good at matching up half siblings. They are always finding 3rd, 4th and 5th cousins of mine but I've only been contacted once. I've never contacted anyone.

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  12. I heard that 23AndMe is having problems and will be going out of business becoz they wanted to Privatize, which is a shame, I'd always thought about using them since perhaps their Data Base was better than Ancestry.com which I wasn't happy with my results and it took them 3 tries to even extract DNA Data I could receive that even could identify at least 70% of my Ancestry, but with that 21% Other of Undetermined Origin. *LOL* I would have also been interested to learn if they've isolated a Gene that gives some Humans the ability to have Premonitions that are uncannily accurate? It runs in my Mom's whole lineage and seems to be a strong trait we pass down Generationally. I get Hangry... I like Meat but found I can easily do without it... and I do have more aggression than the average person, or so I've been told. *Winks* The Man was quite convinced my Mom's Family has Extraterrestrial Ancestry. *Bwahahahaha*

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  13. PS: Jean you can see online where 23AndMe is on the verge of Collapse... I do wonder what will become of all their Genetic Data?

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    1. I don't know! I'm too old to worry about it but I can't believe it wouldn't be preserved by some medical big wigs. Too much potential money to be made on cures in there data base.

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  14. Fingers crossed about the election! Thank you for helping!

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  15. Oh my! You were perplexed by the Guide to the Perplexed...LOL. Good luck with the Harris campaign! Canada is watching with bated breath.

    Deb

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  16. I didn't do 23andme I did ancestry and didn't find any of that information! I may have to try this one. Interesting!

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    1. Ancestry and 23andMe have different missions. I did them both. Ancestry is better for people interested in genealogy and 23andMe is better if you like to explore the science of DNA. I can't remember but I also think 23andMe had different cost points for so you can do just the genealogy part and/or the medical info part. But if you read these comments you'll know that 23andMe may be going out of business soon.

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  17. My sister is interested in genealogy, so she bought me a membership in Ancestry.com. We get lots of information about 3rd and 4th cousins, but nothing about our own bodies.

    I like your letter-writing campaign for Harris. It's nice to do it with a group.

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    1. Ancestry and 23andMe have different missions. I did them both. Ancestry is better for people interested in genealogy and 23andMe is better if you like to explore the science of DNA. I can't remember but I also think 23andMe had different cost points for so you can do just the genealogy part and/or the medical info part. But if you read these comments you'll know that 23andMe may be going out of business soon.

      They say that people actually will read the handwritten political mail as opposed to the mass produced kind. I hope so, but even if they don't it makes me feel like I'm doing something for the cause.

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  18. I just learn so much from your posts! I have zero interest in genealogy and my personal DNA, though I joke I should do it to see if there are any murderers in my family. lol Now after reading this, I'm also wondering what kind of belly button they'd say I have, since I don't have one. (I had an umbilical hernia as a baby and so I have no idea which kind I may have had.)

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    1. That must have been a conversation starter at the beach! LoL Never knew anyone without a belly button.

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